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Amitiza Warnings and Precautions

Conditions you should let your healthcare provider know about before you take Amitiza include liver disease, severe diarrhea, a bowel blockage, or kidney disease. Amitiza warnings and precautions also apply to people who have certain allergies and women who are pregnant or breastfeeding. You should also tell your healthcare provider about any other medications you are taking, including vitamins and herbal supplements.

What Should I Tell My Healthcare Provider Before Taking Amitiza?

You should talk with your healthcare provider prior to taking Amitiza® (lubiprostone) if you have:
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • A bowel blockage (obstruction)
  • Severe diarrhea
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Amitiza Warnings and Precautions

Some warnings and precautions to be aware of prior to taking Amitiza include the following:
  • Your healthcare provider should not prescribe this drug if you have severe diarrhea. Amitiza is meant for people with constipation. Also, let your healthcare provider know if you develop severe or persistent diarrhea while taking it.
  • Amitiza has not been studied in people with liver or kidney disease. These conditions could affect the way your body handles the medication.
  • Nausea is one of the common Amitiza side effects. Taking the medication with food can help minimize this.
  • Some people have reported shortness of breath and/or chest pain after taking a dose of Amitiza. This is not usually considered a serious problem, but it may be unpleasant enough for people to stop taking the medication.
  • Amitiza is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not currently known (see Amitiza and Pregnancy).
  • It is not known if Amitiza passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Amitiza and Breastfeeding).
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Amitiza Medication Information

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