How Does Linzess Work?
Linzess works by binding to an enzyme in the intestines known as guanylate cyclase-C (GC-C). When Linzess binds to GC-C, it causes the enzyme to become active. Activated GC-C increases the amount of fluid in the intestines, and accelerates movement of content through the intestines. This helps relieve symptoms of constipation.
In animal studies, Linzess decreased the activity of pain-sensing nerves in the intestines, which reduced pain. It is unknown whether the drug has the same effect on pain-sensing nerves in humans.
It is worthwhile to note that Linzess works directly in the intestines. It is not absorbed into the bloodstream with normal use.
Is It Safe for Children to Use Linzess?
This drug is only approved for use in adults 18 years of age and older. Linzess may not be safe for use in children. It absolutely must not be given to children under the age of 6 years old, and should not be given to children under the age of 17 years old, as it may harm them.
Can Older Adults Use It?
Older adults can use Linzess. Very few people in Linzess clinical studies were over the age of 65. Therefore, it is unknown whether those older than 65 will tolerate or respond to Linzess any differently than younger age groups. Until more information is available, the medication should probably be used cautiously in older adults.
Off-Label Uses for Linzess
On occasion, your healthcare provider may recommend this medicine for something other than the uses described in this article. This is called an "off-label" use. At this time, there are no universally accepted off-label uses for Linzess.