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Linzess Warnings and Precautions

If you have an intestinal obstruction, tell your healthcare provider before taking Linzess. This drug is not suitable for everyone, and has been known to cause problems for people with certain allergies. Other precautions for using Linzess safely include warnings for women who are pregnant or nursing. Also, this drug should not be used in children younger than 18 years old.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Linzess™ (linaclotide) if you have:
 
  • An intestinal obstruction (a blockage of your bowel)
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
 
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Specific Precautions and Warnings for Linzess

Some warnings and precautions to be aware of prior to taking this drug include the following:
 
  • The most common side effect of Linzess is diarrhea. In most cases, diarrhea begins within two weeks of starting treatment. If you have severe diarrhea while taking Linzess, stop the medication and contact your healthcare provider.
 
  • In animal studies, Linzess caused death when given to young mice. Based on these studies, the medication may not be safe for use in children. Linzess must not be used in children younger than 6 years of age, and should not be used in children age 6 to 17 years old.
   
  • Linzess is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Linzess and Pregnancy).
 
  • It is unknown if Linzess passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Linzess and Breastfeeding).
 

Linzess Medication Information

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