Irritable Bowel Syndrome Channel
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IBS and Lotronex

Lotronex® (alosetron hydrochloride) is a prescription drug used to treat severe diarrhea in women who have irritable bowel syndrome (IBS). Lotronex works by blocking the action of a certain chemical called serotonin. This helps regulate the movement of waste through the intestines, the amount of fluid in stool, and the response to pain and discomfort in the stomach.
Clinical studies have shown that Lotronex reduced IBS symptoms in women who had diarrhea as their main IBS symptom. More specifically, 10 to 19 percent more women who received Lotronex had adequate relief of abdominal (stomach) pain and discomfort, compared with women who received a placebo (a "sugar pill" with no active ingredient).
(Click Lotronex Uses for a closer look at why this IBS medication is prescribed. This article also discusses in more detail how the drug works and explains whether it is used off-label.)
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