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Lotronex Drug Interactions

Lotronex Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when Lotronex is combined with any of the drugs listed above.
 
Apomorphine
The manufacturer of apomorphine recommends it not be used with medications like Lotronex (known as 5-HT3 antagonists), as the combination may cause a dangerously low drop in blood pressure.
 
CYP 1A2 Inhibitor Medications
The body breaks down Lotronex using enzymes in the liver known as CYP 1A2 enzymes. Some other medications (known as CYP 1A2 inhibitors) can decrease the activity of these enzymes. Combining Lotronex with one of these CYP 1A2 inhibitors may increase the amount of Lotronex in the body, potentially increasing your risk for side effects.
 
Lotronex should not be taken in combination with fluvoxamine. Taking it with other CYP 1A2 inhibitors should also be avoided if possible.
 
CYP 2C9 Inhibitor Medications
The liver breaks down Lotronex using enzymes known as CYP 2C9 enzymes, and medications known as CYP 2C9 inhibitors can decrease the activity of these enzymes. Thus, combining Lotronex with one of these drugs may increase the amount of Lotronex in the body, potentially increasing your risk for side effects. While these medicines can be taken together without problems, you may need to watch closely for any possible Lotronex side effects if you take it in combination with a CYP 2C9 inhibitor.
 
CYP 3A4 Inducer Medications
The liver breaks down Lotronex using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Lotronex with one of these drugs may decrease the level of Lotronex in your body, potentially making it less effective. Talk to your healthcare provider if you take Lotronex with a CYP 3A4 inducer, especially if Lotronex is not adequately controlling your symptoms. 
 
CYP 3A4 Inhibitor Medications
The liver breaks down Lotronex using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Lotronex with one of these drugs may increase the level of Lotronex in your body, potentially increasing your risk for Lotronex side effects. Talk to your healthcare provider about this possible interaction if you take these medicines together. Also, let your healthcare provider know if you develop any potential Lotronex side effects.
 
Fluvoxamine
Fluvoxamine can increase blood levels of Lotronex, increasing the risk for potentially serious Lotronex side effects. You should not take Lotronex if you take fluvoxamine.
 

Lotronex Medication Information

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