Irritable Bowel Syndrome Home > Amitiza Side Effects

Some of the most common side effects of Amitiza include nausea, diarrhea, and headaches. In most cases, people have no problems and side effects are generally easy to treat. However, serious Amitiza side effects are possible, which require immediate medical attention. Notify your healthcare provider if you develop severe or persistent diarrhea or signs of an allergic reaction, such as a rash, wheezing, or difficulty swallowing.

An Introduction to Amitiza Side Effects

Just like any medicine, Amitiza® (lubiprostone) can cause side effects. However, not everyone who takes the medication will experience side effects. In fact, most people tolerate it quite well. If Amitiza side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Amitiza. Your healthcare provider can discuss a more complete list of Amitiza side effects with you.)

Common Side Effects of Amitiza

Amitiza has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were documented and then compared to the side effects that occurred in another group of people not taking the medicine. As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the group not taking the medicine.
In these studies, the most common Amitiza side effects included:
  • Nausea -- in up to 29 percent of people
  • Diarrhea -- up to 12 percent
  • Headaches -- up to 11 percent
  • Abdominal pain (stomach pain) -- up to 8 percent
  • Bloating -- up to 6 percent
  • Gas -- up to 6 percent.
Other common side effects (occurring in 1 to 5 percent of people) included:
  • Vomiting
  • Loose stools
  • Abdominal (stomach) discomfort
  • Indigestion or heartburn
  • Dry mouth
  • Dizziness
  • Fatigue
  • Chest pain
  • Fluid retention
  • Shortness of breath.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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