Irritable Bowel Syndrome Home > Lotronex Warnings and Precautions
If you have problems with constipation, blood clots, or diverticulitis, talk to your healthcare provider about whether it is appropriate for you to take Lotronex. Other warnings and precautions with this drug apply to people using certain medications and women who are pregnant or breastfeeding. You should not take it if you have Crohn's disease, ulcerative colitis, or severe liver disease.
What Should I Tell My Healthcare Provider?
You should talk with your healthcare provider prior to taking Lotronex® (alosetron hydrochloride) if you have:
- Constipation, or have had severe constipation or constipation that keeps coming back
- Had intestinal problems due to constipation, including:
- An obstruction (a blockage of your bowel)
- Narrowing (stricture)
- Tear (perforation)
- Widening (toxic megacolon)
- Had problems with blood flow to your intestines, such as ischemic colitis
- Had a blood clot or blood-clotting problems
- Had ulcerative colitis
- Had Crohn's disease
- Had diverticulitis
- Liver disease, such as hepatitis or liver failure
- Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
- Do not understand the Lotronex Medication Guide or Patient Acknowledgement Form, or if you are not willing to follow them
- Are pregnant or thinking of becoming pregnant
- Are breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.