Irritable Bowel Syndrome Home > Lotronex

Lotronex is a drug licensed for the treatment of severe diarrhea-predominant irritable bowel syndrome (IBS) in women. This prescription medicine comes as a tablet that is taken once or twice daily. It is reserved for use in women who have had IBS symptoms for at least six months and have tried other treatments without success. Side effects include nausea, constipation, and abdominal (stomach) pain.

What Is Lotronex?

Lotronex® (alosetron hydrochloride) is a prescription medication approved to treat women with severe diarrhea-predominant irritable bowel syndrome (IBS) who have had symptoms for at least six months, and who have not been adequately helped by other treatments. IBS with diarrhea is considered severe if it is associated with at least one of the following:
  • Frequent and severe abdominal (stomach) pain and discomfort
  • Frequent urgency to have a bowel movement or "accidents" involving loose stools or diarrhea (fecal incontinence)
  • The condition causes disability, or disrupts daily activities at work or home.
Lotronex is not safe for everyone. Because of potentially serious bowel side effects that can occur with Lotronex use, this drug is restricted to people who have severe IBS that has not responded to safer treatments. The medication can only be prescribed by healthcare providers who enroll in a special program and understand the unique benefits and risks of Lotronex treatment. 
(Click Lotronex Uses for more information, including possible off-label uses.)

Who Makes This Medication?

Lotronex is made by Patheon, Inc., for Prometheus Laboratories, Inc. 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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